منابع مشابه
A Rotamer Library to Enable Modeling and Design of Peptoid Foldamers
Peptoids are a family of synthetic oligomers composed of N-substituted glycine units. Along with other "foldamer" systems, peptoid oligomer sequences can be predictably designed to form a variety of stable secondary structures. It is not yet evident if foldamer design can be extended to reliably create tertiary structure features that mimic more complex biomolecular folds and functions. Computa...
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β-Peptoids are peptidomimetics based on N-alkylated β-aminopropionic acid residues (or N-alkyl-β-alanines). This type of peptide mimic has previously been incorporated in biologically active ligands and has been hypothesized to be able to exhibit foldamer properties. Here we show, for the first time, that β-peptoids can be tuned to fold into stable helical structures. We provide high-resolution...
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The design of stimuli-responsive self-assembled molecular systems capable of undergoing mechanical work is one of the most important challenges in synthetic chemistry and materials science. Here we report that foldectures, that is, self-assembled molecular architectures of β-peptide foldamers, uniformly align with respect to an applied static magnetic field, and also show instantaneous orientat...
متن کاملAt most at last
Recent pragmatic accounts derive the ignorance inferences to which superlative modifiers give rise as quantity implicatures in a neo-Gricean framework. While these approaches successfully account for the interaction of at least with modals, the behavior of at most remains a puzzle. I propose that at most is composed of an antonymizing operator and at least and show how this accounts for the int...
متن کاملFree, at last!
Infectious diseases have moulded the development of the human species more than any other biological or abiological factor. They have influenced not only our biology, but also our history and political development; from the outcome of wars to the success of empires, and from the pace of technological advance to the structure of society itself. The introduction of smallpox to the Americas by Eur...
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ژورنال
عنوان ژورنال: Accounts of Chemical Research
سال: 2015
ISSN: 0001-4842,1520-4898
DOI: 10.1021/acs.accounts.5b00257